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AlzRisk Cohort Detail

Cohort: European Studies of Dementia
Risk Factors:

Introduction to the Cohort
This cohort comprises data pooled from four separate European cohorts:

The Odense Study was made up of residents between 65 and 85 living in the municipality of Odense, Denmark. A total of 3,346 participants were randomnly selected and followed up for four years.

The PAQUID study was done in 75 parishes in the provinces Gironde and Dordogne, France. Stratified random sampling was used to select participants from electoral databases. Strata used included age, sex, and size of geographic unit. Participants were required to be at least 65 years old. A total of 5,265 participants were recruited at baseline.

United Kingdom
The MRC-ALPHA study was conducted over an 8 year follow-up period in Liverpool, England. Participants were randomly selected from the
general practitioner registry within strata of age and sex. The baseline cohort consisted of 5,222 participants.

The Netherlands
The Rotterdam study was conducted in Ommoord, part of the municipality of Rotterdam. All individuals over 55 were eligible for participation.7,983 adults were enrolled, of whom 7,046 were deemed to be free of dementia. Since enrollment, participants have undergone evaluations every 2-3 years. Additional follow-up information is available from medical record data.

Ethnicity Breakdown
No ethnicity data was reported but all residents are from European countries.

Diagnosis & Evaluation Methods
For a detailed description, see Launer et al. 1999.

Launer LJ, Andersen K, Dewey ME, Letenneur L, Ott A, Amaducci LA, Brayne C, Copeland JR, Dartigues JF, Kragh-Sorensen P, Lobo A, Martinez-Lage JM, Stijnen T, Hofman A. Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurology. 1999 Jan 1;52(1):78-84.