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AlzRisk Cohort Detail
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Cohort: Neurological Disorders in Central Spain
Risk Factors: Blood Pressure

Introduction to the Cohort
The NEDICES study is a population-based survey of older adults (age 65+) in central Spain. Participants were recruited from three sites: 1) the Margaritas district in Getafe, a suburb of Madrid, 2) the Lista area of Madrid, located int he Salamanca district and 3) an area in Arevalo County, approximately 125 km northwest of Madrid. The study recruited participants by mail from population registries maintained by each municipality. Eligibility criteria required participants to be over 64 years of age and a resident of the area for at least the past 6 months as of December 31, 1993.

At baseline (1994-1995) 5,278 eligible participants completed either a 500-item screening questionnaire in-person or a short form questionnaire via mail. 306 prevalent dementia cases were identified.
At follow-up (1997-1998), participants were re-screened for dementia and study neurologists, interviewers, and supervisors determined which participants would be invited to return for a full evaluation.

Ethnicity Breakdown
Participants were all residents of Spain.

Diagnosis & Evaluation Methods
For detailed description, see Bermejo-Pareja et al. 2009.

References
Bermejo-Pareja F, Benito-Leon J, Louis ED, Trincado R, Carro E, Villarejo A, Gomez de la Camera A. Risk of incident dementia in drug-untreated arterial hypertension: a population-based study. Journal of Alzhiemer's Disease. 2010;22:949-958.

Bermejo-Paraja F, Benito-Leon J, Vega S, Olazaran J, de Toledo M, Diaz-Guzman J, Sanchez-Sanchez F, Morales-Conzalez JM, Trinacado R, Portera-Sanchez A, Roman GC. Consistency of clinical diagnosis of dementia in NEDICES: A population-based longitudinal study in Spain. J Geriat Psychiatry Neurol. 2009;22(4):246-255.

Morales JM, Bermejo FP, Benito-Leon J, Rivera-Navarro J, Trincado R, Gabriel Se R, Vega S, NEDICES Study Group. Methods and demographic findings of the baseline survey of the NEDICES cohort: a door-to-door survey of neurolgical disorders in three communities from central Spain. Public Health. 2004;118:426-433.