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AlzRisk Paper Detail

Reference: Ogunniyi, 2006
Cohort: Indianapolis-Ibadan Dementia Project - Ibadan Cohort
Risk Factor: Alcohol

Average Follow-up Time Detail
Follow-up time was not presented in the article; was presented in the cited article describing the cohorts (Hendrie, et al., JAMA, 2001).

Ethnicity Detail
Participants were of Yoruba ethnicity and residents of Ibadan, Nigeria.

Age Detail
This is the mean age of 1,225 study participants who completed the screening; 531 of the them were clinically assessed and included in this analysis, but the baseline age for this subset was not reported.

Screening and Diagnosis Detail
Screening Method:
CSIDCommunity Screening Interview for Dementia

AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

"Essentially, a two-stage designwas utilized comprising the administration of the Community-Screening Instrument for Dementia (CSI’D) to eligible participants. The incidence study was conducted in two waves – two and five years after the prevalence study. Sub-samples of the study participants were selected for clinical assessment according to established cut-off scores that were derived from discriminant function analysis. Details of these had been described (Hall et al., 1996). The clinical assessment included a structured interview with an informant, neuropsychological testing, and examination by a physician as well as laboratory and imaging studies. All the information obtained was utilized in the consensus diagnosis process within each site, and inter-site agreement was essential before the final diagnoses were recorded. The Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-IIIR) and International Classification of Diseases, 10th Revision (ICD-10) criteria were used to diagnose dementia (American Psychiatric Association, 1987; World Health Organization, 1992). For AD, the National Institute for Neurological and Communicative Diseases and Stroke – Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA) criteria were used (McKhann et al., 1984)."

Covariates & Analysis Detail
Analysis Type:
Logistic regression

AD Covariates: