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AlzRisk Paper Detail
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Reference: Mehta, 1999
Cohort: Rotterdam Study
Risk Factor: Head injury


Average Follow-up Time Detail
We estimated average person-years of follow-up by multiplying the reported average follow-up time by the number of persons.

Exposure Detail
"At baseline, trained research physicians interviewed individuals with a detailed questionnaire at the research center. This questionnaire contained specific questions about previous head trauma, including number of head traumas, age at first and last head trauma, occurrence and duration of loss of consciousness, and post-traumatic amnesia."

The last two categories of head injuries include participants who also make up the second and third categories.

The investigators examined any head injury with loss of consciousness as well as severity and timing of head injury. This entry is for any head injury by severity.

Ethnicity Detail
All participants were residents of a suburb of Rotterdam, The Netherlands. No other information on ethnicity or race has been reported.

Screening and Diagnosis Detail
Screening Method:
CAMDEXCambridge Examination for Mental Disorders of the Elderly
GMSGeriatric Mental State Schedule (Copeland 1976)
MMSEMini-Mental State Examination (Folstein 1975)

AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Total dementia definition: Dementia via DSM-III-R.

"Diagnosis of dementia was made by a panel that reviewed all respondent information using the American Psychiatric Association's criteria (DSM-III-R). [25] A subdiagnosis of AD was based on NINCDS-ADRDA criteria. [26] Vascular dementia was evaluated on the basis of the NINDS-AIREN criteria.[27]"

Covariates & Analysis Detail
Analysis Type:
Logistic regression

AD Covariates:
Aage
Eeducation
Ggender

TD Covariates:
Aage
Eeducation
Ggender