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Papers of the Week
The HBO Alzheimer's Project
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AlzRisk Paper Detail
Non-Steroidal Anti-Inflammatory Drugs
Adult Changes in Thought-Group Health Cooperative
Through a structured interview, participants were asked "Have you ever had an injury so severe that you lost
consciousness?" If the participant responded in the affirmative, he/she was further queried regarding the type of injury (e.g. head) and the age at which it was sustained.
Percentages sum to over 100% since some participants reported more than one ethnicity.
Screening and Diagnosis Detail
Cognitive Abilities Screening Instrument (Teng 1994)
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Total dementia definition
: Dementia via DSM-IV.
"All-cause dementia diagnoses were determined at consensus
conferences using the Diagnostic and statistical manual of mental disorders, 4th edition(DSM-IV) criteria. Probable and possible AD diagnoses were determined using National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association (NINCDS–ADRDA) criteria."
Covariates & Analysis Detail
Cox proportional hazards regression
"The proportional hazards assumption was violated for
dementia models. We compared a variety of parametric models
on the basis of their Akaike Information Criterion values. The best of these were loglogistic, reflecting increased risk over time. For these models we report time ratios. Ratios >1 indicate factors associated with longer survival."
APOE e4 genotype
APOE e4 genotype