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AlzRisk Paper Detail
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Reference: Sundelof, 2009b
Cohort: Uppsala Longitudinal Study of Adult Men
Risk Factor: Nutritional Antioxidants


Average Follow-up Time Detail
The median follow-up was 5.1 years (range 0.2–7.9 years).

Exposure Detail
Blood collection occurred at baseline after an overnight fast and plasma was separated and stored at −70◦C. Serum alpha-tocopherol was analyzed using high performance liquid chromatography (HPLC) with fluorescence detection.

Ethnicity Detail
All participants were residents of Uppsala, Sweden.

Screening and Diagnosis Detail
Screening Method:
MMSEMini-Mental State Examination (Folstein 1975)

AD Diagnosis:
DSM IV Diagnostic and Statistical Manual IV
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Total Dementia Definition: Dementia via DSM IV

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

AD Covariates:
Aage
Eeducation
AIManti-inflammatory medication
APOE4APOE e4 genotype
ASPaspirin
BMIbody mass index
DMdiabetes mellitus
VITEDdietary vitamin E
SMsmoking status
SHstroke history
TCtotal cholesterol
VITCDvitamin C dietary

TD Covariates:
Aage
Eeducation
AIManti-inflammatory medication
APOE4APOE e4 genotype
ASPaspirin
BMIbody mass index
DMdiabetes mellitus
VITEDdietary vitamin E
SMsmoking status
SHstroke history
TCtotal cholesterol
VITCDvitamin C dietary