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AlzRisk Paper Detail
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Reference: Morris, 2006
Cohort: Chicago Health and Aging Project
Risk Factor: B Vitamins


Exposure Detail
Vitamin intake was measured using the baseline questionnaire, a modified Harvard food frequency questionnaire (FFQ) inquiring about usual intake during the past year of 139 food items and vitamin supplements.

Ethnicity Detail
Participants were community residents froma geographically defined biracial population on the south side of Chicago.

Screening and Diagnosis Detail
Screening Method:
CERADConsortium to Establish a Registry for Alzheimer's Disease (Morris 1989)

AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

"Alzheimer’s disease was diagnosed on the basis of structured clinical evaluations that were conducted in participants’ homes by a team consisting of a neuropsychological technician, nurse clinician, phlebotomist, and neurologist. All team members were blinded to dietary and other participant information. The 2 to 3-hour evaluations included neuropsychological testing (using tests of the Consortium Established for Research on Alzheimer’s Disease, CERAD [15]), a complete medical history, medication use, laboratory testing, and neurological examination. Informant interviews were conducted for cognitively impaired participants. The diagnosis of probable Alzheimer’s disease was based on criteria of the joint working group of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and
Associated Disorders Association [16]."

Covariates & Analysis Detail
Analysis Type:
Logistic regression

Nutrient intake was adjusted for total energy intake using the residual method (Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124:17-27).

AD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
VITEDdietary vitamin E
FUTfollow up time
CA-PastPast Cognitive Activity
RErace/ethnicity
NCNTOTLtotal niacin

Models included an interaction term between race (African-American /Caucasian) and APOE ε4 status (any ε4 alleles/none).