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AlzRisk Paper Detail
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Reference: Ravaglia, 2005
Cohort: Conselice Study of Brain Aging
Risk Factor: B Vitamins


Exposure Detail
Baseline venous blood samples were taken after an overnight
fast. Serum samples for folate measurements were sent to the biochemical laboratory for immediate immunoelectrochemiluminescence analysis. Intra- and interassay CVs were 3.1% and 3.8%, respectively.

Ethnicity Detail
Participants were residents from the Italian municipality of Conselice (province of Ravenna, Emilia Romagna region.

Screening and Diagnosis Detail
Screening Method:
MMSEMini-Mental State Examination (Folstein 1975)

AD Diagnosis:
DSM IV Diagnostic and Statistical Manual IV
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Total dementia definition: Dementia via DSM-IV.

"Dementia was defined on the basis of the clinical criteria of the
Diagnostic and Statistical Manual of Mental Disorders, 4th
edition (24). AD was diagnosed on the basis of NINCDS-ADRDA (National Institute of Neurological and Communicative Disease and Stroke–Alzheimer’s Disease and Related Disorders Association) criteria for probable or possible AD [25]. Diagnoses were independently made by 2 physicians (PF and FM) on the basis of all available information. Finally, a diagnostic conference with a third senior physician (RG) was held to discuss each case."

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

AD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
HCYplasma homocysteine
CRTserum creatinine
SHstroke history
VTBvitamin B12

TD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
HCYplasma homocysteine
CRTserum creatinine
SHstroke history
VTBvitamin B12