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AlzRisk Paper Detail

Reference: Corrada, 2005
Cohort: Baltimore Longitudinal Study of Aging
Risk Factor: B Vitamins

Exposure Detail
Intake of dietary vitamin B6 was evaluated using a 7-day food diary during the baseline period. Using this data, the USDA Composition of Food Handbook was used to estimated nutrient intake. Information on supplement intake, including brand name, dosage, and frequency of use, was also recorded.

Ethnicity Detail
No figures were reported, although the population is described in the manuscript as predominately white from the Baltimore, Maryland area.

Screening and Diagnosis Detail
AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

"Medical records, laboratory tests, and informant questionnaires (Dementia Questionnaire)[10,11] were obtained for participants who presented with cognitive problems based on the neurologic examination and neuropsychological tests. The diagnostic status of each subject was assigned during a multidisciplinary conference in which all available information was reviewed. Participants were classified as demented according to criteria from the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised[12]. Diagnosis of AD was based on criteria from the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer’s Disease and Related Disorders Association [13]. Participants who met criteria for probable AD but who did not undergo neuroimaging studies were categorized as “consistent with AD”[14]. Participants whose clinical diagnosis was probable, possible, or “consistent with AD” were included as AD cases in the current study."

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

Time scale for proportional hazards model was age in study.

Total caloric intake was adjusted for as a covariate in the regression model.

AD Covariates:
Kcalcaloric intake
FOLTOTLtotal folate
VitEvitamin E