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AlzRisk Paper Detail

Reference: Blasko, 2008
Cohort: Vienna Trans-danube Aging Cohort
Risk Factor: Homocysteine

Exposure Detail
"Blood samples were collected into polypropylene tubes containing potassium EDTA. The samples were immediately stored on ice and centrifuged within 60 min, and aliquots of plasma were stored at −80 ◦C."

"Homocysteine levels were determined with microparticle enzyme-immunoassay at IMX detection system (Abbott, Wiesbaden, Germany)."

Log-transformed change in homocysteine levels over 2.5 years of follow-up was computed.

Ethnicity Detail
No information on ethnicity was given. However, as the participants were residents of Vienna, they were presumably mostly Caucasian.

Screening and Diagnosis Detail
Screening Method:
CERADConsortium to Establish a Registry for Alzheimer's Disease (Morris 1989)
Neuropsych Testing
TMTTrail Making Test (Reitan 1958)

AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Covariates & Analysis Detail
Analysis Type:
Logistic regression

AD Covariates:
APOE4APOE e4 genotype
CHMTAchange in medial temporal lobe atrophy
CHAB42change in plasma amyloid-beta 42