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AlzRisk Paper Detail
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Reference: Hendrie, 2013
Cohort: Indianapolis-Ibadan Dementia Project - Indianapolis Cohort
Risk Factor: Homocysteine


Average Follow-up Time Detail
Average follow-up time was not reported. However, the maximum follow-up time was 8 years.

Exposure Detail
Plasma homocysteine levels were measured using blood samples collected from 1510 participants in 2001. Samples collected from 503 participants (approximately one-third) were fasting blood samples.

"In 2001, blood samples were drawn from participants who consented. The blood samples were drawn in 10-mL EDTA Vacutainer tubes."

"Samples from Indianapolis were directly processed
at Indiana University. Biochemical analyses were
carried out on the plasma."

Levels of homocysteine were measured using commercial kits from BioRad, Hercules, CA, and Diasorin, Stillwater, MN. For the analysis, baseline plasma homocysteine levels were categorized into quartiles.

Screening and Diagnosis Detail
Screening Method:
CSIDCommunity Screening Interview for Dementia
CERADConsortium to Establish a Registry for Alzheimer's Disease (Morris 1989)
Informant interview
Neuropsych Testing
Other

AD Diagnosis:
DSM IIIR Diagnostic and Statistical Manual III-Revised
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Other

Also used the Clinical Home-based Interview to Assess Function (CHIF) to screen participants and ICD-10 criteria to diagnose dementia.

Covariates & Analysis Detail
Analysis Type:
Logistic regression

AD Covariates:
Aage
Eeducation
APOE4APOE e4 genotype
SMHXhistory of smoking
ORGCHmember of the original cohort

TD Covariates:
Aage
Eeducation
APOE4APOE e4 genotype
SMHXhistory of smoking
ORGCHmember of the original cohort